Microsurgery In Liver Research

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During the last two decades microsurgery has progressively taken the place of macrosurgery since it largely improves the experimental models in liver research. This is a concise but comprehensive ...
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Laboratory Rat Management

Pp. 7-31 (25)

Maria-Angeles Aller, Maria Paz Nava, Marta Mendez, Patri Vergara and Jorge-Luis Arias


Experiments on animals are the key to Surgical Clinical Research; its objective is to solve the unsolved problems in the clinical area. This chapter covers the ethical principles and investigator responsibilities. The principal environmental conditions, such as housing, husbandry and nutrition, are also described. Current studies indicate that rats and mice value opportunities to take cover, build nests, explore, gain social contact, and exercise some control over their social milieu; the inability to satisfy these needs is physically and psychologically detrimental, leading to impaired brain development and behavioral anomalies.


Department of Surgery I. School of Medicine, Complutense University of Madrid. Madrid. Spain.