Lung Macrophages in Health and Disease

Indexed in: Scopus, EBSCO.

This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book consists of 8 chapters which provide a full coverage of macrophage ...
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Critical Clearance: Alveolar Macrophage Recognition of Apoptotic Cells

Pp. 52-61 (10)

Carol Anne Ogden


Apoptotic cell clearance is a vital process by which the body rids itself of unwanted cells, whether they become unwanted due to age, senescence, tissue remodeling and repair, or even damage. Efficient clearance of apoptotic cells depends upon the ability of the phagocyte to recognize and quickly engulf the effete cell before the apoptotic cells can progress to a state of secondary necrosis, spilling out phlogistic and possibly auto-immunogenic contents into the tissue. Removal of apoptotic cells in the lung by alveolar macrophages results in the maintenance of homeostasis, and alveolar macrophage recognition factors control process of clearance.


Immuno-Inflammation Center for Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals.