Nature as Source and Inspiration for the Synthesis of New Anticancer Drugs
Pp. 51-54 (4)
Daniele Passarella, Alessandra Giardini, Giordano Lesma, Alessandra Silvani and Bruno Danieli
The bifunctional taxoid-colchicinoid hybrids were synthesised and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity.
Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, Via Venezian, 21 - 20133 Milano, Italy.