Microcirculation and Insulin Resistance

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Insulin resistance is the main factor involved in the occurrence of the metabolic syndrome and later development of type2 diabetes. Despite decades of research on hormone's target tissues and the ...
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Microvascular Dysfunction: Potential Role in the Pathogenesis of Obesity-Associated Hypertension and Insulin Resistance

Pp. 41-54 (14)

Erik H Serne, Rick I Meijer, Michiel P de Boer, Renate T de Jongh, Richard G IJzerman, Wineke Bakker, Etto C Eringa and Etto C Eringa


The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.


Obesity, hypertension, insulin resistance, microcirculation.


Department of Internal Medicine and 2Laboratory for Physiology, Institute for Cardiovascular Research, VU Medical Centre, Amsterdam, The Netherlands.