Frontiers in Natural Product Chemistry

Volume: 1

Indexed in: Scopus, EBSCO.

“Frontiers in Natural Product Chemistry” is an Ebook series devoted to publishing the latest and most important advances in natural product chemistry. The Ebook series covers all aspects of ...
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The Nitroaldol (Henry) Reaction as the Key Step for the Synthesis of Some Natural Products

Pp. 37-41 (5)

Roberto Ballini, Giovanna Bosica, Dennis Fiorini and Alessandro Palmieri


The nitroaldol (Henry) reaction although has been discovered more than one century ago is still largely employed as the key step for the synthesis of many targets. The reaction is performed under basic condition by mixing primary or secondary nitroalkanes (and nitromethane) with a carbonyl, allowing the formation of a β-nitroalkanol. The latter shows an high versatility since it can be converted into a lot of different functionalities and many natural products have been prepared using the Henry reaction as the key step. Some of these synthesis will be reported.


nitroalkanes, aldehyde, heterogeneous catalysis, condensation, oxidation, chiococca alba, synthesis


Dipartimento di Scienze Chimiche dell'Universita di Camerino, 62032 Camerino, Italy.