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eISBN: 978-1-60805-159-5, 2010 ISBN: 978-1-60805-363-6 ISSN: 2542-5056 (Print) ISSN: 1879-6613 (Online)
Indexed in: Scopus, EMBASE, Book Citation Index, Science Edition, BIOSIS Previews.
“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.
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Pp. 76-105 (30)
Luis Marco, Maria do Carmo Carreiras
Instituto de Quimica Organica General (CSIC), C/ Juan de la Cierva, 3, 28006-Madrid, Spain., Spain
Galantamine is a natural product that has attracted the interest of a number of researchers in a collaborative effort aimed at designing novel biologically active compounds for the treatment of Alzheimer's disease. In this article we review and update the syntheses of racemic and enantiomerically pure galantamine.
Galantamine, biogenetic-type synthesis, total synthesis, phenolic oxidative coupling, para-ortho coupling, PIFA, potassium ferricyanide, intramolecular heck reaction