Experimental Stroke

Experimental Stroke

Indexed in: Scopus

This eBook compiles the efforts of 20 experts in the field to review the latest advances in experimental stroke, with its strong emphasis on neurogenesis, angiogenesis and neuroprotection after ...
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The Use of a Global Statistical Approach for the Design and Data Analysis of Clinical Trials with Multiple Primary Outcomes

Pp. 100-108 (9)

Peng Huang, Robert F. Woolson and Ann-Charlotte Granholm


Determining whether one treatment is preferred over others is a major goal of many clinical studies but can be complicated by the situation when no single outcome is sufficient to make the judgment. We present a useful global statistical test technique and the corresponding global treatment effect (GTE) measure for assessing treatment's global preference when multiple outcomes are evaluated together. Applications of these techniques in clinical trial design and data analysis are illustrated.


Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, USA.