Experimental Stroke

Experimental Stroke

Indexed in: Scopus

This eBook compiles the efforts of 20 experts in the field to review the latest advances in experimental stroke, with its strong emphasis on neurogenesis, angiogenesis and neuroprotection after ...
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Neovascularization Following Cerebral Ischemia

Pp. 26-37 (12)

Rodney Allanigue Gabriel and Guo-Yuan Yang


Neovascularization is the generation of new blood vessels and is made possible either through vasculogenesis, arteriogenesis, or angiogenesis. This process is far from simple as a plethora of growth factors, cytokines and chemokines, and various cell types are required to interact in a collaborative manner in order to initiate and maintain neovasculature. Because neovascularization process occurs following ischemia or traumatic injury, promoting neovascularization is a potential therapeutic approach to these insults. Exogenous regulation of blood vessel formation is therapeutic when it produces functional and stable capillaries, in which newly proliferating microvessels minimally increase blood-brain-barrier permeability and produce adequate regional cerebral blood flow. To review this issue of cerebral neovascularization, we discuss: 1) important angiogenic growth factors, cytokines, extracellular matrix proteins, and cell types involved in brain angiogenesis; 2) involvement of inflammation in cerebral neovascularization; 3) stem cells play a role in cerebral neovascularization; 4) neovascularization following cerebral ischemia in animal model or in clinical cases; and finally 5) neovascularization as a therapeutic target for cerebral ischemic injury.


Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.