Advances in Organic Synthesis

Volume: 2

Modern Organofluorine Chemistry-Synthetic Aspects

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, ...
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Synthesis of Chiral Fluorinated Materials via Biotransformation

Pp. 463-490 (28)

Tomoya Kitazume, Tomoko Matsuda and Kaoru Nakamuraa


Biotransformation of organofluorine materials into the optically active functionalized fluorinated materials along with the discussion on the effect of fluorine atom(s) during the enantioselective and/or diastereoselective transformations is described. The ability of microorganism to discriminate between enantiomers is very important for the purpose of resolution and asymmetric synthesis. Also included are discussions on recent developments in methodologies to control enantioselectivities of catalytic reactions. Examples of practical applications that involve reduction of various types of ketones are also included.


Department of Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.