α,α-Fluoroalkyl(Alkenyl) Amino Reagents (FAR) - Recent Development
Pp. 269-290 (22)
Viacheslav A. Petrov
The review provides an update on the synthesis α-Fluoroalkyl
(alkenyl)Amino Reagents (FAR) and their application for conversion of hydroxyand
carbonyl compounds into the corresponding fluorides.
The first part of the review contains data on the synthesis of FAR by addition of
secondary amines to fluoroolefins, halogen exchange reactions, fluorination of
carbonyl and thiocarbonyl compounds, as well as via electron transfer reactions of
polyfluorinated bromoalkanes. The second section summarizes data on the
physical properties, handling and storage of FAR. The third section of the review
discusses the reactions of FAR with primary, secondary, tertiary, and cyclic
alcohols, as well as sugars, carbonyl and thiocarbonyl compounds, and acids,
which have been developed during the past decade. Recent results on the chemical
transformations of FAR other than fluorination reactions are collected in the final
section of the review.
DuPont Central Research and Development Experimental Station, P.O. Box 80328 Wilmington DE 19880-0328, USA.