Cellular and Molecular Biology of Autism Spectrum Disorders

Indexed in: Chemical Abstracts and Scopus

Over the past several decades the incidence of autism spectrum disorders (ASD) has increased dramatically. The etiology of ASD remains an unsolved puzzle to scientists, physicians, pediatricians, ...
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Gastrointestinal Disorders and Autism Spectrum Disorders: A Causal Link or a Secondary Consequence?

Pp. 82-99 (18)

Anna Strunecka


Growing evidence confirms that up to 95% of autistic children suffer with the dysfunctions of the gastrointestinal (GI) system. We discuss the cellular and molecular mechanisms underlying these disturbances. Some researchers, physicians, and health care professionals suggest that beneficial effects of dietary intervention on behavior and cognition of some autistic children indicate a functional relationship between the GI tract (GIT) and the CNS pathology of ASD. A possible genetic cause for the association of autism and GI disease is discussed. GI disorders are not included in diagnostic criteria for ASD. Clinical and practical experiences provide the support for association between inflammatory bowel disease and ASD.


Department of Physiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.