Electroanalytical Methods as Tools for Predictive Drug Metabolism Studies
Pp. 76-83 (8)
B. Blankert and J. -M. Kauffmann
The search for new in vitro screening tools for early metabolite profiling and identification is
becoming a major focus of interest in the pharmaceutical industry. This is motivated by the hope to avoid
late failure in drug development and ultimately to launch safer drugs with fewer side effects.
Electroanalytical methods alone or coupled on-line with mass spectrometry, can find a niche in this context
as they may be readily implemented for the electrically driven synthesis and characterization of xenobiotics
oxidized or reduced form(s). Intimately integrated in a dual electrode-enzyme configuration, electroanalysis
offers also a mean to study electron transfer at the redox active center of the enzyme in the presence of a
substrate and/or an inhibitor.
Université Libre de Bruxelles – Institute of Pharmacy, Laboratory of Instrumental Analysis and Bioelectrochemistry, Belgium.