In Vivo Studies of α-Particle Radiation Effects Using Zebrafish Embryos
Pp. 263-283 (21)
Kwan Ngok Yu,
Shuk Han Cheng
A brief review on the progress on in vivo studies of α-particle radiation effects using
zebrafish embryos was given in this chapter. The zebrafish, Danio rerio, a small vertebrate from
Southeast Asia, has become a preferred model for studying human disease. The main challenges of these
α-particle radiobiological experiments included quantification of alpha-particle dose. In particular,
specially etched polyallyldiglycol carbonate (PADC) films, which are a kind of solid-state nuclear
track detector (SSNTD), were chosen as support substrates for zebrafish embryos. The fabrication
procedures were outlined. Methods for quantification of alpha-particle dose were described.
Preliminary in vivo studies on the radiation effects of alpha particles in zebrafish embryos were briefly
reviewed. These included results on low-dose radiation effects of α particles as well as results on
alpha-particle-induced bystander effects between zebrafish embryos in vivo.