Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
Pp. 72-83 (12)
Laura E. Alche and Flavia M. Michelini
Many viral infections are associated with the development of immunopathologies and
autoimmune diseases, of difficult treatment, for which no vaccines are available yet. Obtaining
compounds that conjugate both antiviral and immunomodulating activities in the same molecule would
be very useful for the prevention and/or treatment of these immunopathologies of viral origin. Within
this chapter, we present the evaluation of biological properties of synthetic brassinosteroids (BRs)
analogs, and stigmastane and androstane derivatives, as potential antiviral and immunomodulating
agents. We chose three synthetic BRs which had exhibited high antiviral activity against different
human pathogenic viruses. The new steroidal molecules were designed with chemical modifications
from the three BRs, in order to improve their antiviral activity. We also included some structural
moieties responsible for the immunommodulating activity of well-known anti-inflammatory steroids.
Conjunctival cell lines, herpes simplex virus, herpetic stromal keratitis, human corneal cell line.
Laboratorio de Virologia: Agentes antivirales y citoprotectores. Departamento de Quimica Biologica. Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, C1428EGA, Buenos Aires, Argentina.