Anti-Obesity Drug Discovery and Development

Anti-Obesity Drug Discovery and Development

Volume: 1

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory, Scopus

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric ...
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Mitigation Strategies of Obesity-Induced Inflammation and Metabolic Syndrome

Pp. 251-264 (14)

Andreas D. Flouris, Andres E. Carrillo and Giorgos S. Metsios


Obesity is a major global epidemic involving children and adults. According to the World Health Organization, obesity incidence will continue to rise with global estimations reaching 700 million by 2015. Thus, it is essential to investigate the nature of the obesity epidemic and potential mitigating mechanisms. In this chapter, we explore the association between obesity and inflammation and the efficacy of biochemical mimetics such a ghrelin and leptin for exercise and diet in the control of obesity-induced inflammation. We also review non-pharmaceutical obesity interventions and non-invasive means for predicting metabolic syndrome development as well as methods of obesity assessment.


Ghrelin, leptin, exercise, diet, vitamin D, body fat.


FAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for Research and Technology Thessaly, Karies, Trikala, 42100 Greece.