Nephrology and Clinical Chemistry: The Essential Link

Indexed in: Scopus, EBSCO.

Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be ...
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Serum Creatinine: An Old and Modern Marker of Renal Function

Pp. 9-20 (12)

Pierre Delanaye


Serum creatinine is one of the most common blood tests. In this chapter, we review some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. Moreover, analytical and physiological limitations will be described and discussed. The use of the creatinine clearance is also discussed.


Creatinine, glomerular filtration rate, interferences,


Department of Nephrology-Dialysis-Transplantation, University of Liege, CHU Sart-Tilman, Belgium