Frontiers in Natural Product Chemistry

Frontiers in Natural Product Chemistry

Volume: 7

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in ...
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Tetracyclic Benzocarbazoles and Derivatives: Synthesis and Applications

Pp. 158-196 (39)

DOI: 10.2174/9781681089164121070007

Author(s): Francisco Vilaça Gaspar, Joseane Alves Mendes, Paulo Roberto Ribeiro Costa, Miguel Yus, Francisco Foubelo, Camilla Djenne Buarque*

Abstract

Tetracyclic benzocarbazoles are examples of nitrogen-containing heterocycles, which display interesting pharmacological activities and physicochemical properties. This chapter aims to bring some examples about the synthesis of bezocarbazoles, mostly benzo[a]carbazoles (including the dihydro and tetrahydro derivatives), with interesting properties. This chapter also includes aza-pterocarpans and aza-coumestans, which are structurally similar to benzo [a] carbazoles, although their analogous natural products are formed through different biosynthetic pathways. Being aware of the potential interest of these compounds, many efforts have been made for the development of new methodologies to carry out their synthesis and will be discussed below.

Keywords:

Azaarylation, Aza-coumestans, Aza-pterocarpans, Azaspirodecanes, Benzocarbazoles, Chromanones, Chromene, Dihydronaphtalene, Fischer indol, Harmicine, Indole, N-tert-butanesulfinyl imine, Tetralone.