Abstract
SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.
Keywords: Sulfur dioxide, Prodrugs, Drug delivery, Gasotransmitter, Donors, Click and release.
Graphical Abstract
Call for Papers in Thematic Issues
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