OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma

Author(s): Juanjuan Zhong, Jinlan Chen, Bei Wang, Zixian Zhou, Yujie Shen, Yibo Gong, Fangshun Tan, Chengfu Yuan*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 46 , 2021


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Abstract:

Background: It is substantiated that LncRNAs are associated with carcinoma progression. OIP5- AS1 is a tumor-related carcinoma suppressor lncRNA, previously discovered in zebrafish, which is involved in the progression of a variety of cancers, has a regulatory effect on carcinoma, and interacts with miRNA and other biomolecules to affect the physiological and pathological processes of carcinoma cells. This article will discuss the effect of OIP5-AS1 in various cancers and its regulatory mechanism.

Methods: This paper summarized and analyzed OIP5-AS1, which functions on the germination and progression of carcinoma and its regulatory mechanism. Meanwhile, the related research was retrieved and collected by the PubMed system.

Result: OIP5-AS1 is overexpressed in various tumors, which regulates and controls tumor growth and participates in tumor progression, including breast carcinoma, ovarian carcinoma, cervical carcinoma, lung carcinoma, laryngeal squamous cell gastric carcinoma and hepatocellular carcinoma. The research evidence proves that OIP5-AS1 takes part in carcinoma proliferation, growth, migration, invasion, and apoptosis.

Conclusion: OIP5-AS1 probably can be an effective biomarker or a potential therapeutic target in multiple tumors.

Keywords: OIP5-AS1, long noncoding RNA, carcinoma, microRNA, treatment, target.

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Article Details

VOLUME: 27
ISSUE: 46
Year: 2021
Published on: 26 September, 2021
Page: [4699 - 4706]
Pages: 8
DOI: 10.2174/1381612827666210927105558
Price: $65

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