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Current Vascular Pharmacology

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ISSN (Online): 1875-6212

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Systematic Review Article

Thromboprophylaxis in Patients with COVID-19: Systematic Review of National and International Clinical Guidance Reports

Author(s): Konstantinos G. Kyriakoulis, Anastasios Kollias*, Ioannis G . Kyriakoulis, Ioanna A. Kyprianou, Chrysso Papachrysostomou, Panagiotis Makaronis, Rafail A. Kotronias, Dimitrios Terentes-Printzios, Ioannis Toskas and Dimitri P. Mikhailidis

Volume 20, Issue 1, 2022

Published on: 24 August, 2021

Page: [96 - 110] Pages: 15

DOI: 10.2174/1570161119666210824160332

Price: $65

Abstract

Background: Venous Thromboembolism (VTE) is common among patients with severe Coronavirus Disease 2019 (COVID-19). Anticoagulation in hospitalized COVID-19 patients has been associated with survival benefit; however, the optimal thromboprophylaxis strategy has not yet been defined.

Objective: To identify published guidance reports by national and international societies regarding thromboprophylaxis strategies in COVID-19 patients in different settings (outpatients, hospitalized, post-discharge).

Methods: A systematic review of the literature (Pubmed/EMBASE) was conducted independently by two investigators.

Results: Among 1942 initially identified articles, 33 guidance documents were included: 20 published by national and 13 by international societies. These documents provide recommendations mainly for hospitalized (97% of reports) and post-discharge (75%) COVID-19 patients, and less so for outpatients (34%). Thrombotic and bleeding risk stratification prior to any treatment decision is the cornerstone of all suggested thromboprophylaxis strategies; 81% of the documents recommend thromboprophylaxis for all hospitalized patients with a prophylactic dosage of low molecular weight heparin irrespective of VTE risk. Intermediate or therapeutic dose intensity is recommended in high VTE risk patients by 56% and 28% of documents, respectively. Mechanical thromboprophylaxis is suggested in case of high bleeding risk or contraindication to pharmacological thromboprophylaxis (59% of documents). Extended pharmacological thromboprophylaxis is recommended for patients with high VTE risk after hospital discharge (63% of documents). For non-hospitalized outpatients, 28% of documents recommend pharmacological thromboprophylaxis for high VTE risk.

Conclusion: The current guidance identifies thromboprophylaxis in COVID-19 patients, especially during hospitalization, as of major importance for the prevention of VTE. Recommendations are derived from limited evidence from observational studies.

Keywords: Anticoagulation, COVID-19, deep vein thrombosis, guidelines, pulmonary embolism, thromboprophylaxis, venous thromboembolism.

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Graphical Abstract

[1]
Kyriakoulis KG, Kokkinidis DG, Kyprianou IA, et al. Venous thromboembolism in the era of COVID-19. Phlebology 2021; 36(2): 91-9.
[http://dx.doi.org/10.1177/0268355520955083] [PMID: 33249999]
[2]
Kollias A, Kyriakoulis KG, Dimakakos E, Poulakou G, Stergiou GS, Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: Emerging evidence and call for action. Br J Haematol 2020; 189(5): 846-7.
[http://dx.doi.org/10.1111/bjh.16727] [PMID: 32304577]
[3]
Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol 2020; 127: 104362.
[http://dx.doi.org/10.1016/j.jcv.2020.104362] [PMID: 32305883]
[4]
Dimakakos E, Grapsa D, Vathiotis I, et al. H1N1-Induced Venous Thromboembolic Events? Results of a Single-Institution Case Series. Open Forum Infect Dis 2016; 3(4): ofw214.
[http://dx.doi.org/10.1093/ofid/ofw214] [PMID: 28018924]
[5]
Kollias A, Kyriakoulis KG, Lagou S, Kontopantelis E, Stergiou GS, Syrigos K. Venous thromboembolism in COVID-19: A systematic review and meta-analysis. Vasc Med 2021; 26(4): 415-25.
[http://dx.doi.org/10.1177/1358863X21995566] [PMID: 33818197]
[6]
Shi L, Xu J, Duan G, Yang H, Wang Y. The pooled prevalence of pulmonary embolism in patients with COVID-19. Intensive Care Med 2020; 46(11): 2089-91.
[http://dx.doi.org/10.1007/s00134-020-06235-8] [PMID: 32929580]
[7]
Kollias A, Kyriakoulis KG, Stergiou GS, Syrigos K. Heterogeneity in reporting venous thromboembolic phenotypes in COVID-19: Methodological issues and clinical implications. Br J Haematol 2020; 190(4): 529-32.
[http://dx.doi.org/10.1111/bjh.16993] [PMID: 32621757]
[8]
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020; 18(4): 844-7.
[http://dx.doi.org/10.1111/jth.14768] [PMID: 32073213]
[9]
Atallah B, Mallah SI, AlMahmeed W. Anticoagulation in COVID-19. Eur Heart J Cardiovasc Pharmacother 2020; 6(4): 260-1.
[http://dx.doi.org/10.1093/ehjcvp/pvaa036] [PMID: 32352517]
[10]
Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol 2020; 7(6): e438-40.
[http://dx.doi.org/10.1016/S2352-3026(20)30145-9] [PMID: 32407672]
[11]
Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 2020; 18(5): 1094-9.
[http://dx.doi.org/10.1111/jth.14817] [PMID: 32220112]
[12]
Kollias A, Kyriakoulis KG, Syrigos NK, Stergiou GS. Anticoagulation therapy in COVID-19: Is there a dose-dependent benefit? Thromb Res 2021; 199: 19-20.
[http://dx.doi.org/10.1016/j.thromres.2020.12.013] [PMID: 33385796]
[13]
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021; 372(71): n71.
[http://dx.doi.org/10.1136/bmj.n71] [PMID: 33782057]
[14]
COVID-19 Treatment Guidelines. Antithrombotic Therapy in Patients with COVID-19. Available from:https://www.covid19treatmentguidelines.nih.gov/adjunctive-therapy/antithrombotic-therapy/
[15]
Kluge S, Janssens U, Welte T, et al. Recommendations for treatment of critically ill patients with COVID-19 : Version 3 S1 guideline. Anaesthesist 2021; 70(Suppl 1): 19-29.
[http://dx.doi.org/10.1007/s00101-020-00879-3] [PMID: 33245382]
[16]
COVID-19 rapid guideline: Reducing the risk of venous thromboembolism in over 16s with COVID-19 London 2020.
[17]
Patti G, Lio V, Cavallari I, et al. Questions and answers on practical thrombotic issues in SARS-CoV-2 infection: A guidance document from the italian working group on atherosclerosis, thrombosis and vascular biology. Am J Cardiovasc Drugs 2020; 20(6): 559-70.
[http://dx.doi.org/10.1007/s40256-020-00446-6] [PMID: 33145698]
[18]
Chekkal M, Deba T, Hadjali S, et al. Prevention and treatment of COVID-19-associated hypercoagulability: Recommendations of the Algerian society of transfusion and hemobiology. Transfus Clin Biol 2020; 27(4): 203-6.
[http://dx.doi.org/10.1016/j.tracli.2020.09.004] [PMID: 33022374]
[19]
Vanassche T, Orlando C, Vandenbosch K, et al. Belgian clinical guidance on anticoagulation management in hospitalised and ambulatory patients with COVID-19. Acta Clin Belg 2020; 1-6.
[http://dx.doi.org/10.1080/17843286.2020.1829252] [PMID: 33012274]
[20]
Vivas D, Roldán V, Esteve-Pastor MA, et al. Recommendations on antithrombotic treatment during the COVID-19 pandemic. Position statement of the working group on cardiovascular thrombosis of the spanish society of cardiology. Rev Esp Cardiol 2020; 73(9): 749-57.
[http://dx.doi.org/10.1016/j.recesp.2020.04.006] [PMID: 32327870]
[21]
Ramacciotti E, Macedo AS, Biagioni RB, et al. Evidence-based practical guidance for the antithrombotic management in patients with coronavirus disease (COVID-19) in 2020. Clin Appl Thromb Hemost 2020; 26: 1076029620936350.
[http://dx.doi.org/10.1177/1076029620936350] [PMID: 32649232]
[22]
Llau JV, Ferrandis R, Sierra P, et al. SEDAR-SEMICYUC consensus recommendations on the management of haemostasis disorders in severely ill patients with COVID-19 infection. Rev Esp Anestesiol Reanim 2020; 67(7): 391-9. [Engl Ed].
[http://dx.doi.org/10.1016/j.redare.2020.05.007] [PMID: 32591185]
[23]
Khider L, Soudet S, Laneelle D, et al. Proposal of the french society of vascular medicine for the prevention, diagnosis and treatment of venous thromboembolic disease in outpatients with COVID-19. J Med Vasc 2020; 45(4): 210-3.
[http://dx.doi.org/10.1016/j.jdmv.2020.04.008] [PMID: 32571561]
[24]
Orsi FA, De Paula EV, Santos FO, et al. Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: A position paper of the brazilian society of thrombosis and hemostasis and the thrombosis and hemostasis committee of the brazilian association of hematology, hemotherapy and cellular therapy. Hematol Transfus Cell Ther 2020; 42(4): 300-8.
[http://dx.doi.org/10.1016/j.htct.2020.06.001] [PMID: 32565232]
[25]
Susen S, Tacquard CA, Godon A, et al. Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. Crit Care 2020; 24(1): 364.
[http://dx.doi.org/10.1186/s13054-020-03000-7] [PMID: 32560658]
[26]
Kosior DA, Undas A, Kopeć G, et al. Guidance for anticoagulation management in venous thromboembolism during the coronavirus disease 2019 pandemic in Poland: An expert opinion of the Section on Pulmonary Circulation of the Polish Cardiac Society. Kardiol Pol 2020; 78(6): 642-6.
[http://dx.doi.org/10.33963/KP.15425] [PMID: 32515570]
[27]
Linnemann B, Bauersachs R, Grebe M, et al. Venous thromboembolism in patients with COVID-19 (SARS-CoV-2 infection) - a position paper of the German Society of Angiology (DGA). Vasa 2020; 49(4): 259-63.
[http://dx.doi.org/10.1024/0301-1526/a000885] [PMID: 32501145]
[28]
Langer F, Kluge S, Klamroth R, Oldenburg J. Coagulopathy in COVID-19 and its implication for safe and efficacious thromboprophylaxis. Hamostaseologie 2020; 40(3): 264-9.
[http://dx.doi.org/10.1055/a-1178-3551] [PMID: 32498097]
[29]
British Thoracic Society. BTS Guidance on venous thromboembolic disease in patients with COVID-19. Available from: https://www.brit-thoracic.org.uk/covid-19/covid-19-information-for-the-respiratory-community
[30]
Oudkerk M, Büller HR, Kuijpers D, et al. Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. Radiology 2020; 297(1): E216-22.
[http://dx.doi.org/10.1148/radiol.2020201629] [PMID: 32324101]
[31]
Zhai Z, Li C, Chen Y, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: A consensus statement before guidelines. Thromb Haemost 2020; 120(6): 937-48.
[http://dx.doi.org/10.1055/s-0040-1710019] [PMID: 32316065]
[32]
Marietta M, Ageno W, Artoni A, et al. COVID-19 and haemostasis: A position paper from Italian Society on Thrombosis and Haemostasis (SISET). Blood Transfus 2020; 18(3): 167-9.
[http://dx.doi.org/10.2450/2020.0083-20] [PMID: 32281926]
[33]
Casini A, Alberio L, Angelillo-Scherrer A, et al. Thromboprophylaxis and laboratory monitoring for in-hospital patients with COVID-19 - a Swiss consensus statement by the Working Party Hemostasis. Swiss Med Wkly 2020; 150: w20247.
[http://dx.doi.org/10.4414/smw.2020.20247] [PMID: 32277760]
[34]
Chalmers JD, Crichton ML, Goeminne PC, et al. Management of hospitalised adults with coronavirus disease 2019 (COVID-19): A European Respiratory Society living guideline. Eur Respir J 2021; 57(4): 2100048.
[http://dx.doi.org/10.1183/13993003.00048-2021] [PMID: 33692120]
[35]
Cuker A, Tseng EK, Nieuwlaat R, et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv 2021; 5(3): 872-88.
[http://dx.doi.org/10.1182/bloodadvances.2020003763] [PMID: 33560401]
[36]
American Society of Hematology. COVID-19 and VTE/Anticoagulation: Frequently asked questions. Available from:https://www.hematology.org/covid-19/covid-19-and-vte-anticoagulation
[37]
Ahmed HY, Papali A, Haile T, et al. Pragmatic recommendations for the management of anticoagulation and venous thrombotic disease for hospitalized patients with COVID-19 in low- and middle-income countries. Am J Trop Med Hyg 2021; 104(3 Supp): 99-109.
[http://dx.doi.org/10.4269/ajtmh.20-1305] [PMID: 33432908]
[38]
Gerotziafas GT, Catalano M, Colgan MP, et al. Guidance for the management of patients with vascular disease or cardiovascular risk factors and COVID-19: Position paper from VAS-European independent foundation in angiology/vascular medicine. Thromb Haemost 2020; 120(12): 1597-628.
[http://dx.doi.org/10.1055/s-0040-1715798] [PMID: 32920811]
[39]
Costanzo L, Failla G, Antignani PL, et al. The vascular side of COVID-19 disease. Position paper of the International Union of Angiology. Int Angiol 2020; 39(6): 445-51.
[http://dx.doi.org/10.23736/S0392-9590.20.04539-3] [PMID: 32892615]
[40]
Moores LK, Tritschler T, Brosnahan S, et al. Prevention, diagnosis, and treatment of VTE in patients with coronavirus disease 2019: CHEST guideline and expert panel report. CHEST guideline and expert panel report chest 2020; 158(3): 1143-63.
[http://dx.doi.org/10.1016/j.chest.2020.05.559] [PMID: 32502594]
[41]
World Health Organization (WHO). Clinical management of COVID-19. Available from:https://www.who.int/publications/i/item/clinical-management-of-covid-19
[42]
Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and standardization committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost 2020; 18(8): 1859-65.
[http://dx.doi.org/10.1111/jth.14929] [PMID: 32459046]
[43]
Barnes GD, Burnett A, Allen A, et al. Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: Interim clinical guidance from the anticoagulation forum. J Thromb Thrombolysis 2020; 50(1): 72-81.
[http://dx.doi.org/10.1007/s11239-020-02138-z] [PMID: 32440883]
[44]
The European Society for Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Available from:https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance
[45]
Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 2020; 18(5): 1023-6.
[http://dx.doi.org/10.1111/jth.14810] [PMID: 32338827]
[46]
Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: Implications for Prevention, antithrombotic therapy, and follow-Up: JACC State-of-the-art review. J Am Coll Cardiol 2020; 75(23): 2950-73.
[http://dx.doi.org/10.1016/j.jacc.2020.04.031] [PMID: 32311448]
[47]
Flaczyk A, Rosovsky RP, Reed CT, Bankhead-Kendall BK, Bittner EA, Chang MG. Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: Implications for clinical practice and future investigations. Crit Care 2020; 24(1): 559.
[http://dx.doi.org/10.1186/s13054-020-03273-y] [PMID: 32938471]
[48]
Dagens A, Sigfrid L, Cai E, et al. Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: Rapid review. BMJ 2020; 369: m1936.
[http://dx.doi.org/10.1136/bmj.m1936] [PMID: 32457027]
[49]
Gąsecka A, Borovac JA, Guerreiro RA, et al. Thrombotic complications in patients with COVID-19: Pathophysiological mechanisms, diagnosis, and treatment. Cardiovasc Drugs Ther 2021; 35(2): 215-29.
[http://dx.doi.org/10.1007/s10557-020-07084-9] [PMID: 33074525]
[50]
Schulman S, Hu Y, Konstantinides S. Venous thromboembolism in COVID-19. Thromb Haemost 2020; 120(12): 1642-53.
[http://dx.doi.org/10.1055/s-0040-1718532] [PMID: 33099284]
[51]
Fontana P, Casini A, Robert-Ebadi H, Glauser F, Righini M, Blondon M. Venous thromboembolism in COVID-19: Systematic review of reported risks and current guidelines. Swiss Med Wkly 2020; 150: w20301.
[http://dx.doi.org/10.4414/smw.2020.20301] [PMID: 32640479]
[52]
Godino C, Scotti A, Maugeri N. Antithrombotic therapy in patients with COVID-19? - rationale and evidence. Int J Cardiol 2020; 5273(20): 33894-8.
[http://dx.doi.org/10.1016/j.amjcard.2020.05.012] [PMID: 33002521]
[53]
Sakr Y, Giovini M, Leone M, et al. Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A narrative review. Ann Intensive Care 2020; 10: 124.
[http://dx.doi.org/10.1186/s13613-020-00741-0] [PMID: 32953201]
[54]
McBane RD II, Torres Roldan VD, Niven AS, et al. Anticoagulation in COVID-19: A systematic review, meta-analysis, and rapid guidance from mayo clinic. Mayo Clin Proc 2020; 95(11): 2467-86.
[http://dx.doi.org/10.1016/j.mayocp.2020.08.030] [PMID: 33153635]
[55]
Aliberti S, Amati F, Pappalettera M, et al. COVID-19 multidisciplinary high dependency unit: The Milan model. Respir Res 2020; 21(1): 260.
[http://dx.doi.org/10.1186/s12931-020-01516-8] [PMID: 33036610]
[56]
Karimi M, Bozorgi H, Zarei T, et al. Antithrombotic prophylaxis in children and adolescents’ patients with SARS-CoV-2 (COVID-19) infection: A practical guidance for clinicians. Acta Biomed 2020; 91(4): e2020170.
[http://dx.doi.org/10.23750/abm.v91i4.10720] [PMID: 33525215]
[57]
Vogel JP, Tendal B, Giles M, et al. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce. Aust N Z J Obstet Gynaecol 2020; 60(6): 840-51.
[http://dx.doi.org/10.1111/ajo.13270] [PMID: 33119139]
[58]
Kadir RA, Kobayashi T, Iba T, et al. COVID-19 coagulopathy in pregnancy: Critical review, preliminary recommendations, and ISTH registry-communication from the ISTH SSC for Women’s health. J Thromb Haemost 2020; 18(11): 3086-98.
[http://dx.doi.org/10.1111/jth.15072] [PMID: 32846051]
[59]
Guasch E, Brogly N, Manrique S. Practical recommendations in the obstetrical patient with a COVID-19 infection. Rev Esp Anestesiol Reanim 2020; 67(8): 438-45.
[http://dx.doi.org/10.1016/j.redare.2020.06.002] [PMID: 32814634]
[60]
Faden YA, Alghilan NA, Alawami SH, et al. Saudi Society of Maternal-Fetal Medicine guidance on pregnancy and coronavirus disease 2019. Saudi Med J 2020; 41(8): 779-90.
[http://dx.doi.org/10.15537/smj.2020.8.25222] [PMID: 32789417]
[61]
Ávila-Castro D, Ortiz-Torres G, Sánchez-Jara B, et al. Proposal for the management of COVID-19-associated coagulopathy in children. Gac Med Mex 2020; 156(4): 344-53.
[http://dx.doi.org/10.24875/GMM.M20000417] [PMID: 32831339]
[62]
Kluge S, Janssens U, Welte T. Empfehlungen zur intensivmedizinischen therapie von patienten mit COVID-19 – 3. Pneumologe (Berl) 2020; 1-12.
[http://dx.doi.org/10.1007/s00101-020-00833-3]
[63]
Vazquez FJ, Korin J, Baldessari EM. Recomendaciones para el uso de tromboprofilaxis en pacientes hospitalizados por COVID-19 en la Argentina. Medicina (B Aires) 2020; 80(Suppl. 3): 65-6.
[PMID: 32658849]
[64]
Hellenic Society of Hematology. Recommendations for thromboprophylaxis in patients with COVID-19. Available from:https://www.eae.gr/el/information/guidelines/item/924-systaseis-thromvoprofylaksis-se-astheneis-me-covid-19-tmima-aimostasis-e-a-e
[65]
Rodriguez JJ, Munoz OC, Porres-Aguilar M, Mukherjee D. Thromboembolic complications in severe COVID-19: Current antithrombotic strategies and future perspectives. Cardiovasc Hematol Disord Drug Targets 2021; 21(1): 23-9.
[http://dx.doi.org/10.2174/1871529X21666210315123347] [PMID: 33719953]
[66]
Enoxaparin for primary thromboprophylaxis in ambulatory patients with COVID-19. Available from: https://clinicaltrials.gov/ct2/show/NCT04400799
[67]
Poulakou G, Dimakakos E, Kollias A, et al. Beneficial effects of intermediate dosage of anticoagulation treatment on the prognosis of hospitalized COVID-19 patients: The ETHRA study. In Vivo 2021; 35(1): 653-61.
[http://dx.doi.org/10.21873/invivo.12305] [PMID: 33402523]
[68]
Mikhailidis DP, Barradas MA, O’donoghue S, Dandona P. Evidence for in vivo platelet activation following the injection of conventional unfractionated heparin. Platelets 1990; 1(4): 189-92.
[http://dx.doi.org/10.3109/09537109009005487] [PMID: 21043946]
[69]
Barradas MA, Mikhailidis DP, Epemolu O, Jeremy JY, Fonseca V, Dandona P. Comparison of the platelet pro-aggregatory effect of conventional unfractionated heparins and a low molecular weight heparin fraction (CY 222). Br J Haematol 1987; 67(4): 451-7.
[http://dx.doi.org/10.1111/j.1365-2141.1987.tb06168.x] [PMID: 2447931]
[70]
Sadeghipour P, Talasaz AH, Rashidi F, et al. Effect of intermediate-dose vs standard-dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID-19 admitted to the intensive care Unit: The INSPIRATION randomized clinical trial. JAMA 2021; 325(16): 1620-30.
[http://dx.doi.org/10.1001/jama.2021.4152] [PMID: 33734299]
[71]
Kollias A, Poulakou G, Dimakakos E, Kyriakoulis KG, Syrigos K. Thromboprophylaxis in COVID-19: Early initiation might be as important as optimal dosing. Thromb Res 2021; 204: 134-5.
[http://dx.doi.org/10.1016/j.thromres.2021.06.004] [PMID: 34144797]
[72]
Roberts LN, Whyte MB, Georgiou L, et al. Postdischarge venous thromboembolism following hospital admission with COVID-19. Blood 2020; 136(11): 1347-50.
[http://dx.doi.org/10.1182/blood.2020008086] [PMID: 32746455]
[73]
Rosovsky RP, Sanfilippo KM, Wang TF, et al. Anticoagulation practice patterns in COVID-19: A global survey. Res Pract Thromb Haemost 2020; 4(6): 969-83.
[http://dx.doi.org/10.1002/rth2.12414] [PMID: 32838111]
[74]
Vaughn VM, Yost M, Abshire C, et al. Trends in venous thromboembolism anticoagulation in patients hospitalized with COVID-19. JAMA Netw Open 2021; 4(6): e2111788.
[http://dx.doi.org/10.1001/jamanetworkopen.2021.11788] [PMID: 34115129]

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