Lipid Engineered Nanoparticle Therapy for Burn Wound Treatment

(E-pub Ahead of Print)

Author(s): Abdul Qadir, Usama Ahmad, Asad Ali, Aisha Shahid, Mohd. Aqil, Nausheen Khan, Athar Ali, Waleed H Almalki, Saad Alghamdi, Md Abul Barkat, Sarwar Beg

Journal Name: Current Pharmaceutical Biotechnology


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Abstract:

Introduction: Skin is the largest organ of the human body protecting the underlying organs and tissues from any foreign attack. Any damage caused in the skin may sometimes result in serious consequences within the internal body tissues. Burn is one such issue that damages the layers of the skin and thereby making the skin vulnerable and prone to any foreign matter entering and causing serious diseases.

Methods: An online literature assessment was steered for the lipid nanoparticles, burn wound treatments, and different types of nanoformulation. Appropriate information was taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar etc. Additional data was summarized from textbooks, local prints and scripts.

Results: Recent innovations and developments in nanotechnology-based drug delivery systems have shown promising results in minimizing the drawbacks associated with conventional therapies. Lipid based nanoparticles possess capabilities to deliver active agents to their target site without the possibility of degradation. Conventional therapy of burn wound is costly and the treatment is long lasting, making the patient uncomfortable. Moreover, it also doesn’t yield satisfactory results or narrow effects. Encapsulation of bioactives inside the lipid core protects the active entity from pH and enzymatic degradations.

Conclusion: This review highlights the drawbacks associated with conventional dosage forms. A lot of consideration is focused on the advancement of nanomaterials using innovative methods in wound care for treating burn wounds with a faster healing effect. This review article highlights recent developments in lipid based nanoformulations for the treatment of burn wound injury.

Keywords: Burn, injury, nanoparticles, lipids, wound healing, liposomes, niosomes, ethosomes.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389201022666210823110532
Price: $95

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