Bis-triazole-containing Compounds with Anticancer Potential: A Short Review

Author(s): Meixiang Gao, Qiang Diao, Feng Gao, Xiangyang Sun*, Jiaqi Xiao*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 18 , 2021

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Graphical Abstract:


The development of novel anticancer agents with high efficiency is of great importance due to the severe anticancer scenario of the currently used drugs. Dimerization is a useful method to develop new drug candidates with a broad biological spectrum, enhanced activity and potency to overcome drug resistance. A wide variety of bis-triazole-containing compounds have been developed with improved properties compared with their parent compounds. These derivatives could inhibit tumor proliferation, invasion and metastasis, revealing their potential as putative anticancer candidates. This review covers the recent advances of bis-triazole-containing compounds as anticancer candidates, and the structure-activity relationship are also discussed to set up the direction for the design and development of bis-triazole-containing compounds with higher efficiency.

Keywords: 1, 2, 3-triazole, 1, 2, 4-triazole, Dimers, Hybrids, Anticancer, Structure-activity relationship, Dimerization.

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Article Details

Year: 2021
Published on: 28 July, 2021
Page: [1674 - 1691]
Pages: 18
DOI: 10.2174/1568026621666210728154728
Price: $65

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