The development of novel anticancer agents with high efficiency is of great importance
due to the severe anticancer scenario of the currently used drugs. Dimerization is a useful method
to develop new drug candidates with a broad biological spectrum, enhanced activity and potency to
overcome drug resistance. A wide variety of bis-triazole-containing compounds have been developed
with improved properties compared with their parent compounds. These derivatives could inhibit
tumor proliferation, invasion and metastasis, revealing their potential as putative anticancer
candidates. This review covers the recent advances of bis-triazole-containing compounds as anticancer
candidates, and the structure-activity relationship are also discussed to set up the direction
for the design and development of bis-triazole-containing compounds with higher efficiency.
Keywords: 1, 2, 3-triazole, 1, 2, 4-triazole, Dimers, Hybrids, Anticancer, Structure-activity relationship, Dimerization.
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