Asymmetric Organocatalytic Syntheses of Bioactive Compounds

(E-pub Ahead of Print)

Author(s): Estibaliz Sansinenea, Aurelio Ortiz*

Journal Name: Current Organic Synthesis


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Abstract:

Background: The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds.

Objective: In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day.

Results: An asymmetric organocatalytic reaction is a key to generate stereoselectively the main structure with the required stereochemistry.

Conclusion: Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with sub-strates are also described.

Keywords: Organocatalysis, organocatalytic process, organocatalytic cascade reactions, asymmetric synthesis, natural products, stereoselec-tivity, catalyst.

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Article Details

Published on: 28 July, 2021
(E-pub Ahead of Print)
DOI: 10.2174/1570179418666210728145206
Price: $95

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