Nanomachines hold promise for the next generation of emerging technology; however, nanomachines
are not a new concept. Viruses, nature’s nanomachines, have already existed for thousands
of years. In 2019, the whole world had to come together to confront a life-threatening nanomachine
named “SARS-CoV-2”, which causes COVID-19 illness. SARS-CoV-2, a smart nanomachine,
attaches itself to the ACE2 and CD147 receptors present on the cell surfaces of the lungs,
kidneys, heart, brain, intestines, testes, etc. and triggers pathogenesis. Cell entry triggers a cascade of
inflammatory responses resulting in tissue damage, with the worst affected cases leading to death.
SARS-CoV-2 influences several receptors and signalling pathways; therefore, finding a biomaterial
that caps these signalling pathways and ligand sites is of interest. This research aimed to compare the
similarities and differences between COVID-19 and its elderly sisters, MERS and SARS. Furthermore,
we glanced at emerging therapeutics that carry potential in eliminating SARS-CoV-2, and the
tissue damage it causes. Simple prophylactic and therapeutic strategies for the treatment of COVID-
19 infection have been put forward.