Green Hydrotropes-Assisted Route: An Alternative Approach for Extracting Phytoconstituents and Associated Drug Delivery Systems

Author(s): Devika Tripathi*, Nandini Chaudhary, Pranay Wal, Awani K. Rai, Jagannath Sahoo

Journal Name: Drug Delivery Letters

Volume 11 , Issue 3 , 2021

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Critically challenging tasks for the researchers are isolating and extracting chief active medicinal phytoconstituents from existing herbal plants. The intricate extraction process usually involves active plant and animal portions separated by selective solvents through various standard procedures. Therefore, most of the products contained the complex metabolites mixtures, making the extraction process involved in separating these products increasingly tricky, thus resulting in lesser yield. Therefore, an alternative strategy suitable for green extraction routes has recently succeeded as a sustainable resource with many advantages like high solvency, low toxicity, and low impact in the environment, biodegradable, and helps recycle consumed solvents without showing any detrimental effects on the environment.

The process of green hydrotrope-assisted extraction process persists a novel and promising methodology that maximizes the yield of phytoconstituents in comparison to the conventional extraction process by the commissioning of a variety of hydrotropes like sodium cumene sulfonate, sodium alkyl-benzene sulfonates, and sodium butyl mono-glycol sulfate, involved in selective extraction of water-insoluble phytoconstituents by the disorganization of the phospholipid bilayers by the hydrotrope, through cell permeabilization, disruption of the cellulosic cell wall and, then possibly the dissolution of the cellular contents.

The central point of this audit is the increase of the surrender of phytoconstituents from herbal plants accomplished by considering green hydrotropic-assisted extraction process, an assignment of carrying out the extraction of herbal plants sanctioning hydrotropes and its component. Using hydrotropes for extracting the phytoconstituents has imperatively highlighted the conveyance frameworks of separated extricated phytoconstituents from herbal plants and encourages the forwarding of their bioavailability at distinctive target destinations.

Keywords: Hydrotrope-assisted process, hydrotropes, green solvent, herbal plants, extraction phytoconstituents, mechanism, drug delivery system.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2021
Published on: 11 July, 2021
Page: [220 - 232]
Pages: 13
DOI: 10.2174/2210303111666210712100722
Price: $25

Article Metrics

PDF: 267