Gut-Brain-Microbiota Axis and Hypertension: A Literature Review

Author(s): Young Nam Kwon, Yong-Jae Kim*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 37 , 2021


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Abstract:

The gut and brain are linked via various bidirectional pathways, and they communicate withand affect each other. The interaction between the gut-brain axis and the gut microbiota has attracted much attention in the development of hypertension. In this review, we have discussed the gut-brain-microbiota axis and its association with gut dysbiosis in terms of regulation of blood pressure using the autonomic nervous system, immune system, metabolites, hormones, and neurotransmitters. In addition, the treatments using microbiota that have been tried, to date, are briefly summarized. By understanding the mechanism by which gut-brainmicrobiota regulates blood pressure, the novel targets for hypertension treatment or a new therapeutic approach using the gut-brain-microbiota could be investigated.

Keywords: Gut-brain-axis, hypertension, microbiota, neurology, immune system, short-chain fatty acids, angiotensin II.

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Article Details

VOLUME: 27
ISSUE: 37
Year: 2021
Published on: 06 July, 2021
Page: [3939 - 3946]
Pages: 8
DOI: 10.2174/1381612827666210706161733
Price: $65

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