Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches

Author(s): João L.P. Ribeiro, Cláudia Alves, Ana L. Cardoso, Susana M.M. Lopes, Teresa M.V.D. Pinho e Melo*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 19 , 2021

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Graphical Abstract:


The asymmetric reduction of oximes and hydrazones is an attractive and versatile strategy for the synthesis of chiral amines, which are valuable building blocks in organic synthesis. This review summarizes the relevant developments made in the last decade on the enantioselective and diastereoselective reduction of oximes and hydrazones involving metalcatalyzed hydrogenation/hydrogenolysis reactions, hydride donor reactions, and electrochemical reactions.

Keywords: Chiral amines, asymmetric reduction, enantioselective reduction, diastereoselective reduction, oximes, chiral hydroxylamines, hydrazones, chiral hydrazines.

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Article Details

Year: 2021
Published on: 06 July, 2021
Page: [2175 - 2198]
Pages: 24
DOI: 10.2174/1385272825666210706151631
Price: $65

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PDF: 164