Abstract
Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals.
Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials.
In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom economy that starts from inexpensive reagents, such as alkenes.
This review aims to provide an updated overview of hydroaminomethylation as a useful tool for synthesizing aliphatic secondary and tertiary amines. Therefore, the discussion will focus on both unsaturated starting compounds and the amines obtained by this one-pot reaction.
Keywords: Amines, hydroaminomethylation, terminal olefins, internal olefins, oleochemicals, terpenes, asymmetric catalysis.
Current Organic Chemistry
Title:Amines via Hydroaminomethylation: An Updated Overview
Volume: 25 Issue: 16
Author(s): Carmela G. Arena*
Affiliation:
- Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universita di Messina, Viale F. Stagno D’Alcontres, 31 Vill. S. Agata, Messina,Italy
Keywords: Amines, hydroaminomethylation, terminal olefins, internal olefins, oleochemicals, terpenes, asymmetric catalysis.
Abstract:
Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals.
Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials.
In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom economy that starts from inexpensive reagents, such as alkenes.
This review aims to provide an updated overview of hydroaminomethylation as a useful tool for synthesizing aliphatic secondary and tertiary amines. Therefore, the discussion will focus on both unsaturated starting compounds and the amines obtained by this one-pot reaction.
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Cite this article as:
Arena G. Carmela *, Amines via Hydroaminomethylation: An Updated Overview, Current Organic Chemistry 2021; 25 (16) . https://dx.doi.org/10.2174/1385272825666210706124548
DOI https://dx.doi.org/10.2174/1385272825666210706124548 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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