Amines via Hydroaminomethylation: An Updated Overview

Author(s): Carmela G. Arena*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 16 , 2021

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Graphical Abstract:


Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals.

Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials.

In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom economy that starts from inexpensive reagents, such as alkenes.

This review aims to provide an updated overview of hydroaminomethylation as a useful tool for synthesizing aliphatic secondary and tertiary amines. Therefore, the discussion will focus on both unsaturated starting compounds and the amines obtained by this one-pot reaction.

Keywords: Amines, hydroaminomethylation, terminal olefins, internal olefins, oleochemicals, terpenes, asymmetric catalysis.

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Article Details

Year: 2021
Published on: 06 July, 2021
Page: [1831 - 1852]
Pages: 22
DOI: 10.2174/1385272825666210706124548

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PDF: 73