Amide-Directed Reactions of Small Carbocycles

Author(s): Pavel M. Yamanushkin, Marina Rubina, Michael Rubin*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 14 , 2021

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


The topic of this review is the amide-directed functionalization of strained carbocycles - specifically, unsaturated or saturated three- and four-membered rings. The following approaches are discussed: a) directed carbometallation and hydrometallation of cyclopropenes catalyzed by transition metals; b) directed metal-templated nucleophilic addition reactions; c) directed C-H functionalization, including transition metal-catalyzed C-H-activation reactions; and d) directed radical additions.

Keywords: Small cycles, directing groups, nucleophilic addition, C-H activation, transition metal-catalysis, radical additions.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2021
Published on: 06 July, 2021
Page: [1686 - 1703]
Pages: 18
DOI: 10.2174/1385272825666210706124215

Article Metrics

PDF: 49