Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection

Author(s): Qingfeng Guan, Biswajit Bhowmick, Archana Upadhyay, Qian Han*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 13 , 2021


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Abstract:

Outer membrane protein A (OmpA) is a unique outer membrane protein which is abundantly present in the outer membrane of Gram-negative bacteria. OmpA is a transmembrane structural protein with a conserved amino acid sequence among different bacteria. This protein is involved in a number of functions like adhesion, toxicity, invasiveness, and biofilm formation in Gram-negative bacteria. Many studies have proposed that OmpA could be a therapeutic target for bacterial infection. Our review focusses on the studies involving recent development in the structure and functions of OmpA and further discussing its potential as a therapeutic target for bacterial infection.

Keywords: OmpA, Structure, Function, Therapeutic target, Gram-negative bacteria, Biofilm.

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Article Details

VOLUME: 21
ISSUE: 13
Year: 2021
Published on: 05 July, 2021
Page: [1129 - 1138]
Pages: 10
DOI: 10.2174/1568026621666210705164319
Price: $65

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