Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues

Author(s): Sepideh Shekari, Fatemeh Khonsha, Mohammad Rahmati-Yamchi, Hamid R. Nejabati*, Ali Mota*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 46 , 2021

Become EABM
Become Reviewer
Call for Editor


Non-alcoholic fatty liver disease (NAFLD), a growing health issue around the world, is defined as the presence of steatosis in the liver without any other detectable byproducts such as alcohol consumption, which includes a wide spectrum of pathologies, such as steatohepatitis, cirrhosis, and hepatocellular carcinoma. A growing body of evidence indicates that the reduction in the 5' adenosine monophosphate-activated protein kinase (AMPK) activity, which could be activated by the consumption of the drugs, hormones, cytokines, and dietary restriction, is related to some metabolic disorders such as obesity, diabetes, PCOS, and NAFLD. Vanillic acid (VA), as an anti-inflammatory, anti-oxidative, anti-angiogenic and anti-metastatic factor, has protective effects on the liver as in two animal models of liver damage, it reduces serum levels of transaminases, inflammatory cytokines, and the accumulation of collagen in the liver and also prevents liver fibrosis. Besides, it decreases body and adipose tissue weight in a mice model of obesity and, similar to the liver tissue, diminishes adipogenesis through the activation of AMPK. It has been reported that VA can target almost all of the metabolic abnormalities of NAFLD, such as hepatic steatosis, inflammation, and hepatic injury, at least partially through the activation of AMPK. Therefore, in this review, we will discuss the possible and hypothetical roles of VA in NAFLD, with a special focus on AMPK.

Keywords: NAFLD, AMPK, VA, hepatic injury, inflamation, fatty liver.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2021
Published on: 01 July, 2021
Page: [4686 - 4692]
Pages: 7
DOI: 10.2174/1381612827666210701145438
Price: $65

Article Metrics

PDF: 52