Herbal remedies have been employed for the treatment and management of different diseases
for ages. Herbal medicines are a promising choice over modern synthetic drugs because of
their low side effects and are thus considered to be safe and effective in treating human diseases.
Lagenaria siceraria (Mol.) Standley fruit (Bottle gourd) belongs to the Cucurbitaceae family that
has been used in a different system of traditional medication to treat various diseases. This is a domestic
plant that provides food as well as medication. This vegetable have low caloric values and
high water contents. The edible portion of it contains phytochemicals like vitamins, proteins, choline,
minerals, terpenoids, flavonoids, etc. Several bioactive compounds have been isolated from L.
siceraria, including triterpenoids, sterols, cucurbitacins, flavones, C-glycosides and β-glycosides.
Researchers have evaluated various parts of this plant viz. fruit, root, flowers, and leaves for pharmacological
activities like antianxiety, antidepressant, diuretic, antimicrobial, cytotoxic, antihyperlipidemic,
cardio protective, analgesic, anti-inflammatory, anthelmintic, anti-hyperglycemic, antihepatotoxic,
anti-urolithiatic, antistress, antiulcer, anticancer, hepatoprotective, anthelmintic, immunomodulatory,
and antioxidant. In this review, an attempt has been made to explore its phytochemical
constituents, traditional, medicinal, and pharmacological uses to highlight the therapeutic importance
of this well-known plant. This would be helpful in reviving its importance and will highlight
its several promising aspects to encourage researchers for further research on L. siceraria.