Effect of Hydroxychloroquine on Lipid Levels: A Systematic Review and Metaanalysis

Author(s): Luis E. Simental-Mendía*, Mario Simental-Mendía, Adriana Sánchez-García, Enrique Linden-Torres

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 40 , 2021


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Abstract:

Background: It has been suggested that hydroxychloroquine may have positive effects on LDL-C, HDL-C, and triglyceride levels; however, the hypolipidemic activities of this drug are still uncertain.

Objective: The aim of this meta-analysis of randomized controlled trials was to explore the effect of hydroxychloroquine on circulating lipid concentrations.

Methods: Randomized controlled trials examining the impact of hydroxychloroquine on lipid parameters were searched in PubMed, Web of Science, Scopus, and Google Scholar databases. Meta-analysis was performed using a random-effects model and sensitivity analysis through the leave one-out method.

Results: Meta-analysis showed that patients receiving hydroxychloroquine therapy significantly decreased total cholesterol (WMD: 0.18 mmol/L, 95% CI: -0.28, -0.08, I2 = 6%, p = 0.0004), LDL-C (WMD: -0.21 mmol/L, 95% CI: -0.36, -0.06, I2 = 75%, p = 0.006), triglycerides (WMD: -0.09 mmol/L, 95% CI: -0.15, -0.04, I2 = 22%, p = 0.001), and non-HDL-C (WMD: -0.28 mmol/L, 95% CI: -0.45, -0.12, I2 = 0%, p = 0.0009), and increased HDL-C concentrations (WMD: 0.03 mmol/L, 95% CI: 0.00, 0.06, I2 = 0%, p = 0.03).

Conclusion: Our results suggest that hydroxychloroquine improves lipid parameters by reducing total cholesterol, LDL-C, triglycerides, non-HDL-C, and increasing HDL-C levels.

Keywords: Hydroxychloroquine, lipid profile, HDL-C, LDL-C, non-HDL-C, total cholesterol, triglycerides.

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Article Details

VOLUME: 27
ISSUE: 40
Year: 2021
Published on: 25 June, 2021
Page: [4133 - 4139]
Pages: 7
DOI: 10.2174/1381612827666210625162612
Price: $65

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