Background: It has been suggested that hydroxychloroquine may have positive effects on LDL-C,
HDL-C, and triglyceride levels; however, the hypolipidemic activities of this drug are still uncertain.
Objective: The aim of this meta-analysis of randomized controlled trials was to explore the effect of hydroxychloroquine
on circulating lipid concentrations.
Methods: Randomized controlled trials examining the impact of hydroxychloroquine on lipid parameters were
searched in PubMed, Web of Science, Scopus, and Google Scholar databases. Meta-analysis was performed using
a random-effects model and sensitivity analysis through the leave one-out method.
Results: Meta-analysis showed that patients receiving hydroxychloroquine therapy significantly decreased total
cholesterol (WMD: 0.18 mmol/L, 95% CI: -0.28, -0.08, I2 = 6%, p = 0.0004), LDL-C (WMD: -0.21 mmol/L,
95% CI: -0.36, -0.06, I2 = 75%, p = 0.006), triglycerides (WMD: -0.09 mmol/L, 95% CI: -0.15, -0.04, I2 = 22%,
p = 0.001), and non-HDL-C (WMD: -0.28 mmol/L, 95% CI: -0.45, -0.12, I2 = 0%, p = 0.0009), and increased
HDL-C concentrations (WMD: 0.03 mmol/L, 95% CI: 0.00, 0.06, I2 = 0%, p = 0.03).
Conclusion: Our results suggest that hydroxychloroquine improves lipid parameters by reducing total cholesterol,
LDL-C, triglycerides, non-HDL-C, and increasing HDL-C levels.