The development of simple, atom-economical, and sustainable methodologies for
the construction of various functional molecules from easily available substrates has been of
great interest in synthetic chemistry. N,N-dimethylformamide (DMF) is an inexpensive, abundant
solvent and industrial raw material, and it is considered as an effective polar solvent and
also as a versatile reagent in synthetic transformations. During the past few decades, many
significant and attractive achievements have been made in the fields of DMF as a reactant.
The mini-review will mainly summarize recent advance in the applicants of DMF as a multipurpose
building block in synthetic reactions.
Keywords: N, N-dimethylformamide, DMF, building block, organic solvent, versatile reactant, synthetic transformation, synthetic chemistry.
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