Structural Phylogeny of Different Allergens May Reveal Common Epitopic Footprint

Author(s): Anubhab Laha, Anindya Sundar Panja, Rajib Bandopadhyay*

Journal Name: Protein & Peptide Letters

Volume 28 , Issue 10 , 2021


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Abstract:

Background: The incidence of allergy has been increasing at an alarming rate over the last few decades.

Objective: Our present study aims to find out the structurally homologous motifs present in different proteinaceous allergens.

Methods: Significant number of protein sequences and their corresponding structures of various pollen, fungal, bacterial, and food allergens were retrieved and the sequence and structural identity were analyzed.

Results: Intra- and inter-sequence along with their structural analysis of the proteinaceous allergens revealed that no significant relationships exist among them. A few, but not the negligible number of high structural similarities, were observed within different groups of allergens from fungus, angiosperms, and animals (Aves and Mammalia).

Conclusion: Our in silico study on thirty-six different allergens showed a significant level of structural similarities among themselves, regardless of their sequences.

Keywords: Allergy, allergen, epitope, hypersensitivity, structural homology, protein sequences.

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Article Details

VOLUME: 28
ISSUE: 10
Year: 2021
Published on: 22 June, 2021
Page: [1099 - 1107]
Pages: 9
DOI: 10.2174/0929866528666210622145710
Price: $95

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