Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Author(s): Junjie Zhong, Wendi Xuan, Mengting Tang, Shihao Cui, Yuhang Zhou, Xiaosheng Qu*, Xin Cao*, Bing Niu*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 13 , 2021


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Abstract:

ANO1, anoctamin 1(also known as TMEM16A), is the molecular basis of calcium-activated chloride channels with ten transmembrane segments which are widely expressed in mammalian cells, including epithelial cells, vascular smooth muscle tissues, electro-excitatory cells, and some tumor cells. To date, multiple studies have shown that many natural and synthetic compounds have regulatory effects on ANO1. Therefore, ANO1 could be a potential new drug target for the treatment of cancer, pain, diarrhea, hypertension, and asthma. In this study, we review the structure of ANO1 and its involvement in cancer, pain, diarrhea, hypertension, and asthma.

Keywords: Anoctamin 1, CaCCs, Cancer, Hypertension, Asthma, Pain, Heart disease, Diarrhea.

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Article Details

VOLUME: 21
ISSUE: 13
Year: 2021
Published on: 07 June, 2021
Page: [1139 - 1155]
Pages: 17
DOI: 10.2174/1568026621666210607125614
Price: $65

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