Background: The impact of personalized medicine is potentially enormous, but the genetic
results are often difficult to integrate into health settings. A number of research studies are
emerging to aid in translating pharmacogenomics into clinical practice.
Objective: We aimed to create a standardized process to guide the implementation of dose adjustment
recommendations into the electronic health record (EHR).
Materials and Methods: Monographs were created for selected drug-gene pairs, allowing for a
standardized review of available evidence. A scoring template was developed to assess whether the
evidence presented in the drug monograph qualified the mentioned drug-gene pair for Clinical Decision
Support (CDS) within the EHR.
Results: Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to
the institution’s governing pharmacogenomics committee.
Conclusion: This project resulted in the development of a standard process for reviewing pharmacogenomics-
related literature, allowing for more CDS proposals to be accepted.