The oral drug delivery route is preferable to deliver the therapeutic agents because of the
low cost, flexibility in dosage form, and easy administration of drugs responsible for a high range
of patient compliance. GRDDS is also an oral route of drug delivery system to prolong gastric residence
time, thereby achieving site-specific drug release in the upper GIT for local or systemic effect.
Various strategies for developing systematic GRDDS include approaches with less density
than stomach contents, systems with high density, swellable and expanding strategies, formulation
of super porous hydrogels, gas generating systems, hydrodynamically balanced, raft forming approaches,
floating drug delivery, and dual working systems. The massive challenge in developing
systemic GRDDS is inter and intra-individual differences in gastric physiology. Despite so many
formulation strategies, these systems might be associated with few benefits as well as drawbacks.
Drawbacks with few approaches can be overthrown by formulating novel dual working systems
such as a Mucoadhesive Floating Drug Delivery System (MFDDS). These systems can form an intimate
contact of the formulation with the stomach's mucosal membrane and increase the dosage formulation's
absorption at the target site. The present compilation aims to outline the stomach's physiological
state, the ideal characteristics of drugs for GRDDS, key factors impacting GRDF efficacy,
and gastroretentive formulation strategies that could become the critical processes in the pharmaceutical
research for target drug delivery. It also explores various marketed products of GRDDS
and future perspectives.