Abstract
Most of the biologically active microbial natural products and their analogs bear a complex molecular architecture. The semisynthetic modifications and stereospecific diversity- oriented synthesis of these native natural products to generate analogs are difficult and time-consuming. Mutasynthesis is a powerful tool that utilizes the microorganism's genetic and metabolic engineering skills to produce derivatives of complex natural products of microbial origin. Mutasynthesis is based on the cellular uptake of chemically modified intermediates from the culture media and their addition to the secondary metabolism by mutant microorganisms. This review will describe the importance of mutasynthesis in the generation of complex microbial secondary metabolites. We have covered a literature search on mutasynthesis over the last ten years (2011-2020) in this review.
Keywords: Mutasynthesis, precursor directed biosynthesis, gene, biosynthesis, combinatorial, secondary metabolites.
Current Organic Chemistry
Title:Mutasynthesis of Medicinally Significant Natural Products Through Manipulation of Gene Governing Starter Unit
Volume: 25 Issue: 13
Author(s): Parul Grover, Deepak K. Sharma, Anuj K. Chhalodia and Debaraj Mukherjee*
Affiliation:
- Natural Product & Medicinal Chemistry (NPMC), Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001,India
Keywords: Mutasynthesis, precursor directed biosynthesis, gene, biosynthesis, combinatorial, secondary metabolites.
Abstract: Most of the biologically active microbial natural products and their analogs bear a complex molecular architecture. The semisynthetic modifications and stereospecific diversity- oriented synthesis of these native natural products to generate analogs are difficult and time-consuming. Mutasynthesis is a powerful tool that utilizes the microorganism's genetic and metabolic engineering skills to produce derivatives of complex natural products of microbial origin. Mutasynthesis is based on the cellular uptake of chemically modified intermediates from the culture media and their addition to the secondary metabolism by mutant microorganisms. This review will describe the importance of mutasynthesis in the generation of complex microbial secondary metabolites. We have covered a literature search on mutasynthesis over the last ten years (2011-2020) in this review.
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Cite this article as:
Grover Parul , Sharma K. Deepak , Chhalodia K. Anuj and Mukherjee Debaraj *, Mutasynthesis of Medicinally Significant Natural Products Through Manipulation of Gene Governing Starter Unit, Current Organic Chemistry 2021; 25 (13) . https://dx.doi.org/10.2174/1385272825666210603102557
DOI https://dx.doi.org/10.2174/1385272825666210603102557 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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