Background: There is a possible relation between red blood cell distribution width
(RDW) and various clinical conditions. These conditions can render RDW disadvantageous in its
relation with cardiovascular disease. There may be a relation between the severity of acute
coronary syndrome (ACS) and the percentage of hypochromia (hypo%), percentage of
hyperchromia (hyper%), percentage of macrocytosis (MAC%), and percentage of microcytosis
(MIC%) values measured using new-generation hematological devices.
Objective: We aimed to examine the relation between the SYNTAX score and the hypo%, hyper%,
MAC%, and MIC% values in patients admitted with ACS.
Method: A group of 55 patients who underwent coronary angiography with diagnosis of ACS
(STEMI and NSTEMI) and a control group of 48 patients with normal coronary arteries were
included in the study. Venous blood samples were collected in the morning after a fasting of at
least 8 h and analyzed using standard laboratory methods. Hemogram parameters were studied
using Alinity HQ (Abbott, USA) a completely automated hemogram autoanalyzer. Biochemical
parameters were studied using Architect c16000 (Abbott, USA) a completely automated
Results: Significant difference was observed in erythrocyte morphology-related tests (mean
corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration,
RDW, hypo%, hyper%, MIC%, and MAC%) between the groups. Correlation analysis showed a
positive correlation between the SYNTAX score and MAC% (r = 0.315, p = 0.019). Multivariate
logistic regression analysis was performed for MAC% to identify the independent predictors of the
SYNTAX score (β = 0.315, p = 0.019).
Conclusion: Changes in MAC% test can be measured in emergencies with new-generation
hematological devices and used as independent predictors of the presence of severe coronary artery