Background: Cassia tora has been classified as an antifungal agent, but no
optimized formulation for improved drug penetration has been developed.
Objective: The present work aimed to formulate Cassia Tora Extract (CTE) phytosomal
gel that could be used for its antifungal effects and improved therapeutic activity.
Materials and Methods: The CTE phytosomes were formulated by varying the concentration
of lecithin (0.15-0.25% w/v) and speed of rotation (100-160 rpm). A 22 factorial
design was applied by taking the above two parameters as independent variables and vesicular
size and entrapment efficiency as dependent variables. The phytosomes were also
evaluated for polydispersity index, zeta potential and in vitro drug release. The optimized
phytosomes of CTE were further developed into a gel, the optimized gel was also
evaluated, and the stability studies were conducted.
Results and Discussion: The optimized CTE phytosome showed a vesicular size of ~
124 nm and entrapment efficiency of 95%. The CTE phytosomes showed a drug release
of 58.79% in 24 hours following the Higuchi order of release. The CTE phytosomes
were formulated into a gel by using 1% Carbopol 934 and were evaluated for pH, viscosity
and homogeneity. The formulated gel showed better penetration than conventional
gel, and stability changes indicated no major changes to the CTE phytosomal gel.
Conclusion: The optimized gel had better penetration and drug release than the conventional
gel. Its therapeutic activity, therefore, can be enhanced.