Trends of Pharmaceutical Design of Endophytes as Anti-infective

Author(s): Pragya Tiwari*, Yashdeep Srivastava, Hanhong Bae*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 17 , 2021


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Abstract:

Plant-endophyte associations represent an inexhaustible source of novel metabolites, exhibiting significance in environment, agriculture and pharmaceutical perspectives. The global outbreak of life-threatening diseases necessitates a need for a more targeted approach through efficient drug-discovery programs. In recent times, endophytes as “bio-factories” have been extensively explored for the production of novel bioactive metabolites demonstrating therapeutic properties. Resources in computational biology co-integrated with combinational chemistry have made significant contributions in this field, aiding in discovery and screening of potential “drug-like” molecules from endophytes. The review provides a meta-analysis of bioactive metabolite production from endophytes, extensively discussing the bio-prospection of natural products for pharmaceutical applications. In light of emerging importance of endophytes as anti-infective agents, an exploration of the pharmaceutical design of novel chemical entities and analogues has enabled efficient and cost-effective drug discovery programs. However, bottlenecks in endophyte biology and research require a better understanding of endophyte dynamics and mechanism of bioactive metabolite production towards a sustainable drug discovery program.

Keywords: Anti-infective, Bioactive, Bio-prospection, Drug discovery, Endophytes, Natural products, Pharmaceutical design.

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Article Details

VOLUME: 21
ISSUE: 17
Year: 2021
Published on: 23 May, 2021
Page: [1572 - 1586]
Pages: 15
DOI: 10.2174/1568026621666210524093234
Price: $65

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