Background: 5-Fluorouracil is an anti-metabolite compound used for several years as
an anti-tumor drug. The development of a gastroretentive drug delivery system of 5-Fluorouracil
may have advantages since they retain in the stomach for an extended time and release the drug in
a sustained manner, which ultimately enhances the absorption of the drug and consequently the
Objective: The objective of the present work was to prepare a sesame oil-entrapped gellan gum hydrogel
bead for controlled stomach specific delivery of 5-Fluorouracil.
Methods: Sesame oil-entrapped gellan gum hydrogel bead was prepared by ionotropic gelation
method. The developed hydrogels were characterized by SEM, FTIR, DSC, and XRD. The entrapment
efficiency, floating ability, swelling and drug release in vitro were also determined.
Results: Electrostatic interaction between the carboxylic group of polymers and Ca++ was confirmed
by FTIR analysis. The SEM photograph of the hydrogel beads portrayed an approximately
spherical shaped structure. DSC thermogram and XRD spectra exhibited the molecular dispersion
of the drug inside the hydrogel beads. The developed beads of 5-Fluorouracil floated in pH 1.2 buffer
solutions for a prolonged time period and the duration of floating was improved significantly
with increasing the concentration of oil. The developed formulations showed controlled release of
drug and incorporation of oil retarded the release of the drug. Fickian and non-Fickian mechanism
of drug transport was observed from the prepared hydrogel beads.
Conclusion: Overall, the oil-entrapped gellan matrices could be used for the intragastric delivery
of 5-Fluorouracil to treat stomach cancer.