Step Economy in the Stereoselective Synthesis of Functionalized Oxindoles via Organocatalytic Domino/One-pot Reactions

Author(s): Martina Bortolami, Francesca Leonelli, Marta Feroci, Fabrizio Vetica*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 11 , 2021


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Abstract:

Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

Keywords: Oxindoles, organocatalysis, domino reactions, one-pot reactions, cascade reactions, asymmetric synthesis, chiral building blocks, bioactive compounds.

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Article Details

VOLUME: 25
ISSUE: 11
Year: 2021
Published on: 24 May, 2021
Page: [1321 - 1344]
Pages: 24
DOI: 10.2174/1385272825666210518124845

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