Step Economy in the Stereoselective Synthesis of Functionalized Oxindoles via Organocatalytic Domino/One-pot Reactions

Author(s): Martina Bortolami, Francesca Leonelli, Marta Feroci, Fabrizio Vetica*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 11 , 2021

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

Keywords: Oxindoles, organocatalysis, domino reactions, one-pot reactions, cascade reactions, asymmetric synthesis, chiral building blocks, bioactive compounds.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2021
Published on: 24 May, 2021
Page: [1321 - 1344]
Pages: 24
DOI: 10.2174/1385272825666210518124845

Article Metrics

PDF: 40