Oxindoles are an important class of heterocyclic scaffolds widely present in natural
products and bioactive compounds. For this reason, a plethora of methodologies for the
stereoselective synthesis of enantioenriched oxindoles has been studied over the years.
Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool
for the asymmetric synthesis of this class of compounds being a step- and atom-economical,
environmentally friendly, and non-toxic approach. This review will outline the application of
asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on
domino/one-pot reaction sequences in a step-economical fashion.
Keywords: Oxindoles, organocatalysis, domino reactions, one-pot reactions, cascade reactions, asymmetric synthesis, chiral building blocks,
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