What is New in Gastroenterology and Hepatology

What is New in Gastroenterology and Hepatology

Note: This book has been published under Bentham’s FAST TRACK OPEN ACCESS publication option upon the author’s request. The finalized book will be published soon.

Gastroenterology and hepatology represent dynamic fields of study and practice in internal medicine, with numerous innovations manifesting over the last 30 years. What is New in Gastroenterology and ...
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New Insights into NAFLD (Diagnosis, Risk Stratification, Treatment)

Pp. 253-266 (14)

DOI: 10.2174/9781681087870121010024

Author(s): Carmen Braticevici Fierbinţeanu, Alexandru Moldoveanu*

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, with a worldwide prevalence of 25%. Considering the ongoing obesity epidemic, the rise in diabetes, and other features of metabolic syndrome, the prevalence of NAFLD along with the proportion of those with advanced liver disease is expected to increase continuously. NAFLD/NASH patients have a high comorbidity burden; those with advanced liver disease have significantly higher costs, especially for patients requiring hospitalization. Early identification and effective management is needed to minimize the disease progression and costs. Experts reached a consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease “MAFLD” was suggested as a more appropriate overarching term. Until now the biggest unmet need is a performant biomarker that can diagnose and stage NASH to replace the need for liver biopsy. Such a biomarker, will increase the ability to identify patients at risk, monitor disease progression, and response to the therapy. Treatments need a multidisciplinary approach and include: drugs targeting intake and disposal energy, lipotoxic liver injury, inflammation and fibrogenesis that lead to cirrhosis.

Keywords:

Biomarkers, Diabetes Mellitus, Disease Progression, Liver Cirrhosis, Metabolic Associated Fatty Liver Disease, Metabolic Syndrome, Liver Biopsy, Non-alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity.