What is New in Gastroenterology and Hepatology

What is New in Gastroenterology and Hepatology

Note: This book has been published under Bentham’s FAST TRACK OPEN ACCESS publication option upon the author’s request. The finalized book will be published soon.

Gastroenterology and hepatology represent dynamic fields of study and practice in internal medicine, with numerous innovations manifesting over the last 30 years. What is New in Gastroenterology and ...
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Precision Medicine in Inflammatory Bowel Disease: Current Challenges

Pp. 91-103 (13)

DOI: 10.2174/9781681087870121010010

Author(s): Eugen Dumitru, Cristina Tocia*

Abstract

Inflammatory bowel diseases are chronic relapsing diseases with an increasing incidence worldwide, with variable and unpredictable evolution, as well as predisposition to complications throughout the disease. Despite the efforts of the academic world of research, their etiology remains incompletely elucidated, but intense research over the last decade showed that they are based on intricate complex pathophysiological mechanisms that occur in the genome, epigenome, microbiome, or immunome. Precision medicine is a new concept and its application in inflammatory bowel disease consists of adapting medical treatment to each patient who is viewed from an individual perspective, encompassing a multitude of evidence-based approaches in the literature, thus facilitating accurate medical decisions. Significant progress has been made by studying genomic data such as genome, transcriptome, proteome, metabolome, and microbiome. With a wide range of treatments available, the demand for precision medicine in inflammatory bowel disease is of paramount importance. The goal of precision medicine is to provide individualized care so that the patient's voyage from diagnosis to treatment is based on the individual biological characteristics. Precision medicine, in order to adapt one specific therapy to a specific patient at one specific time based on the patient's biological characteristics, is an important aspiration in the medical world. Although much progress has been made in this area, some challenges remain unclear. In the future, precision medicine has the capacity to provide personalized care to patients with inflammatory bowel disease.

Keywords:

Epigenome, Genetics, Genome, Immunity, Inflammatory bowel disease, Microbiome, Precision medicine, Proteomics.