Eosinophilic Gastrointestinal Disorders
Pp. 26-42 (17)
Dan L. Dumitraşcu*,
Andrei V. Pop
Eosinophilic infiltration of the gut occurs unusually and its clinical relevance
was only recently recognized. The medical conditions with eosinophilic infiltration are
commonly named eosinophilic gastrointestinal disorders [EGID]. EGID is described as
a gastrointestinal tract disorder with functional and morphological abnormalities due to
a dense infiltration of eosinophils in the gastrointestinal wall. The cause could be an
allergic reaction due to varied allergens, food or the environment. EGID is including
eosinophilic esophagitis [EoE], eosinophilic gastroenteritis [EGE], and eosinophilic
EGIDs pathophysiology is not yet fully understood, but histopathology is characterized
by degranulation and an excessive number of eosinophils. A role in the
pathophysiology of EGIDs is played by a hypersensitive reaction. Diagnosing EGIDs is
quite challenging. It can be described as a combination of eosinophilic invasion of one
or more organs from the GI tract with non-specific GI symptoms. The gold standard for
EGIDs diagnosis is the histology of gastrointestinal mucosal biopsy, an overabundance
of eosinophils being the principal diagnostic criterion without a known cause.
The treatment for EGID is not well defined yet, because of the limited prospective
controlled studies performed. The treatment is an empiric one and is administrated
according to the severity of the symptoms and it is represented by diet, corticosteroids,
and steroid agents.
Eosinophilic gastrointestinal disorders, Eosinophilic esophagitis,
Eosinophilic gastroenteritis, Eosinophilic colitis, Hypersensitive reaction.