Background: N,N'-Diacylhydrazines are involved in many synthetic transformations.
The current work reviews the synthesis of N,N'-diacylhydrazines and their use in various
Results: Three synthetic routes are commonly used to produce N,N'-diacylhydrazines. They are
produced through the coupling of acyl chlorides and carbohydrazides, the reaction of hydrazine
hydrate and carboxylic acids or isocyanates, and the dimerization of carbohydrazides. They can
be oxidized to produce the corresponding esters and act as precursors in the synthesis of various
heterocycles such as 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles, pyrazoles,
tetrazines, and crown ethers.
Conclusions: Various synthetic procedures have been reported for the production of N,N'-
diacylhydrazines. N,N'-Diacylhydrazines are involved in the synthesis of various heterocycles.