Synthesis of N,N'-Diacylhydrazines and their Use in Various Synthetic Transformations

Author(s): Mohammed A. Baashen*

Journal Name: Current Organic Chemistry

Volume 25 , Issue 12 , 2021

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Graphical Abstract:


Background: N,N'-Diacylhydrazines are involved in many synthetic transformations. The current work reviews the synthesis of N,N'-diacylhydrazines and their use in various synthetic transformations.

Results: Three synthetic routes are commonly used to produce N,N'-diacylhydrazines. They are produced through the coupling of acyl chlorides and carbohydrazides, the reaction of hydrazine hydrate and carboxylic acids or isocyanates, and the dimerization of carbohydrazides. They can be oxidized to produce the corresponding esters and act as precursors in the synthesis of various heterocycles such as 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles, pyrazoles, tetrazines, and crown ethers.

Conclusions: Various synthetic procedures have been reported for the production of N,N'- diacylhydrazines. N,N'-Diacylhydrazines are involved in the synthesis of various heterocycles.

Keywords: N, N`-Diacylhydrazines, insecticides, heterocycles, 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles, 1, 2, 4-triazoles.

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Article Details

Year: 2021
Published on: 25 May, 2021
Page: [1394 - 1403]
Pages: 10
DOI: 10.2174/1385272825666210505105032
Price: $65

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