Intracranial Cerebrospinal Fluid Volume Evaluation in Healthy People and Hydrocephalus Patients using SPACE Sequence

Author(s): Xiaofeng Wu, Seidu A. Richard, Xu Xiangdong, Zhang Lirong, Wu Min*

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 17 , Issue 7 , 2021


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Graphical Abstract:


Abstract:

Introduction: Cerebrospinal Fluid (CSF) is produced mainly by the choroid plexus but with a substantial influence by the ependymal lining of the ventricles in the brain. Hydrocephalus occurs as a result of discrepancy in the production as well as circulation of CSF as a result of congenital and acquired conditions. Nevertheless, studies on the differences between CSF dynamics according to age and gender are still insufficient. Thus, this study evaluated the volume of intracranial CSF in healthy people and hydrocephalus patients taking into account the differences between CSF dynamics according to age and gender using Sampling Perfection with Application optimised Contrast using different flip-angle Evolution (SPACE) sequence.

Methods: 120 healthy volunteers and 60 patients with hydrocephalus were included in this study. SPACE sequence was used to evaluate intracranial CSF with a 3.0T magnetic resonance machine. The total volume of intracranial CSF and the amount of CSF in the ventricle were obtained using a software, and the volume ratio of CSF in the subarachnoid space, the ventricle and the subarachnoid space were calculated.

Results: The mean volume of intracranial CSF, ventricular CSF, and subarachnoid CSF of male volunteers were (206.9±47.7) cm3, (33.0±10.7) cm3, (173.9±37.9) cm3 respectively. The average volume of intracranial CSF, ventricular CSF, and subarachnoid CSF of female volunteers were (199.7±44.9) cm3, (30.8±9.4) cm3, and (168.9±37.0) cm3, respectively. Thus, no significant statistically (P>0.05) difference between males and females was found. (3) The mean values of intracranial CSF, ventricle CSF and subarachnoid CSF, ventricle and subarachnoid CSF volume ratio in patients with hydrocephalus were significantly greater than health volunteers. Thus, the difference between the two groups was statistically significant (P<0.05).

Conclusion: SPACE sequence can quantitatively determine the content of CSF. The change of CSF volume has nothing to do with gender but with age. It is feasible to use SPACE sequence to evaluate the spatial distribution and volume of intracranial CSF.

Keywords: CSF, hydrocephalus, intracranial, ICP, SPACE, volunteers.

[1]
Thompson DN. Hydrocephalus. Surgery 2009; 27: 130-4.
[http://dx.doi.org/10.1016/j.mpsur.2009.02.005]
[2]
Kahle KT, Kulkarni AV, Limbrick DD Jr, Warf BC. Hydrocephalus in children. Lancet 2016; 387(10020): 788-99.
[http://dx.doi.org/10.1016/S0140-6736(15)60694-8] [PMID: 26256071]
[3]
Capone PM, Bertelson JA, Ajtai B. Neuroimaging of normal rressure hydrocephalus and hydrocephalus. Neurol Clin 2020; 38(1): 171-83.
[http://dx.doi.org/10.1016/j.ncl.2019.09.003] [PMID: 31761057]
[4]
Koleva M, De Jesus O. StatPearls Publishing 2020; LLC: 2020.
[5]
Farb R, Rovira À. IDKD springer series hydrocephalus and CSF disorders.Diseases of the brain, head and neck, spine 2020-2023: Diagnostic imaging. Cham (CH): Springer 2020; pp. 11-24.
[6]
Hodel J, Silvera J, Bekaert O, et al. Intracranial cerebrospinal fluid spaces imaging using a pulse-triggered three-dimensional turbo spin echo MR sequence with variable flip-angle distribution. Eur Radiol 2011; 21(2): 402-10.
[http://dx.doi.org/10.1007/s00330-010-1925-1] [PMID: 20725835]
[7]
Hodel J, Besson P, Rahmouni A, et al. 3D mapping of cerebrospinal fluid local volume changes in patients with hydrocephalus treated by surgery: Preliminary study. Eur Radiol 2014; 24(1): 136-42.
[http://dx.doi.org/10.1007/s00330-013-2990-z] [PMID: 23979107]
[8]
Wagshul ME, Chen JJ, Egnor MR, McCormack EJ, Roche PE. Amplitude and phase of cerebrospinal fluid pulsations: Experimental studies and review of the literature. J Neurosurg 2006; 104(5): 810-9.
[http://dx.doi.org/10.3171/jns.2006.104.5.810] [PMID: 16703889]
[9]
Tsunoda A, Mitsuoka H, Sato K, Kanayama S. A quantitative index of intracranial cerebrospinal fluid distribution in normal pressure hydrocephalus using an MRI-based processing technique. Neuroradiology 2000; 42(6): 424-9.
[http://dx.doi.org/10.1007/s002349900241] [PMID: 10929302]
[10]
Lemieux L, Hammers A, Mackinnon T, Liu RS. Automatic segmentation of the brain and intracranial cerebrospinal fluid in T1-weighted volume MRI scans of the head, and its application to serial cerebral and intracranial volumetry. Magn Reson Med 2003; 49(5): 872-84.
[http://dx.doi.org/10.1002/mrm.10436] [PMID: 12704770]
[11]
Fan Z, Yang Q, Deng Z, et al. Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid-attenuated T1-weighted 3D turbo spin echo. Magn Reson Med 2017; 77(3): 1142-50.
[http://dx.doi.org/10.1002/mrm.26201] [PMID: 26923198]
[12]
Hodel J, Lebret A, Petit E, et al. Imaging of the entire cerebrospinal fluid volume with a multistation 3D SPACE MR sequence: Feasibility study in patients with hydrocephalus. Eur Radiol 2013; 23(6): 1450-8.
[http://dx.doi.org/10.1007/s00330-012-2732-7] [PMID: 23239062]
[13]
Meindl T, Wirth S, Weckbach S, Dietrich O, Reiser M, Schoenberg SO. Magnetic resonance imaging of the cervical spine: Comparison of 2D T2-weighted turbo spin echo, 2D T2*weighted gradient-recalled echo and 3D T2-weighted variable flip-angle turbo spin echo sequences. Eur Radiol 2009; 19(3): 713-21.
[http://dx.doi.org/10.1007/s00330-008-1175-7] [PMID: 18813933]
[14]
Lichy MP, Wietek BM, Mugler JP III, et al. Magnetic resonance imaging of the body trunk using a single-slab, 3-dimensional, T2-weighted turbo-spin-echo sequence with high sampling efficiency (SPACE) for high spatial resolution imaging: Initial clinical experiences. Invest Radiol 2005; 40(12): 754-60.
[http://dx.doi.org/10.1097/01.rli.0000185880.92346.9e] [PMID: 16304477]
[15]
Stadlbauer A, Salomonowitz E, Brenneis C, et al. Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: Preliminary results. Eur Radiol 2012; 22(1): 232-42.
[http://dx.doi.org/10.1007/s00330-011-2247-7] [PMID: 21863368]
[16]
Houtchens MK, Benedict RH, Killiany R, et al. Thalamic atrophy and cognition in multiple sclerosis. Neurology 2007; 69(12): 1213-23.
[http://dx.doi.org/10.1212/01.wnl.0000276992.17011.b5] [PMID: 17875909]
[17]
Benedict RH, Bruce JM, Dwyer MG, et al. Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Arch Neurol 2006; 63(9): 1301-6.
[http://dx.doi.org/10.1001/archneur.63.9.1301] [PMID: 16966509]
[18]
Voskuhl RR, Patel K, Paul F, et al. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ 2020; 11(1): 49.
[http://dx.doi.org/10.1186/s13293-020-00326-3] [PMID: 32859258]
[19]
Benedict RH, Weinstock-Guttman B, Fishman I, Sharma J, Tjoa CW, Bakshi R. Prediction of neuropsychological impairment in multiple sclerosis: Comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden. Arch Neurol 2004; 61(2): 226-30.
[http://dx.doi.org/10.1001/archneur.61.2.226] [PMID: 14967771]
[20]
Lebret A, Hodel J, Rahmouni A, Decq P, Petit E. Cerebrospinal fluid volume analysis for hydrocephalus diagnosis and clinical research. Comput Med Imaging Graph 2013; 37(3): 224-33.
[http://dx.doi.org/10.1016/j.compmedimag.2013.03.005] [PMID: 23570816]
[21]
Rovaris M, Comi G, Filippi M. MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction. J Neurol Sci 2006; 245(1-2): 111-6.
[http://dx.doi.org/10.1016/j.jns.2005.07.014] [PMID: 16626748]
[22]
Bendel P, Koivisto T, Aikiä M, et al. Atrophic enlargement of CSF volume after subarachnoid hemorrhage: Correlation with neuropsychological outcome. AJNR Am J Neuroradiol 2010; 31(2): 370-6.
[http://dx.doi.org/10.3174/ajnr.A1804] [PMID: 19942696]
[23]
Wang Y-h, Zhang X-t, Yang F-m. Study of intracranial volume of cerebrospinal fluid of healthful chinese adults by using stereotactic MRI technique. Chinese Journal of Clinical Neurosurgery 2008; 12
[24]
Luetmer PH, Huston J, Friedman JA, et al. Measurement of cerebrospinal fluid flow at the cerebral aqueduct by use of phase-contrast magnetic resonance imaging: Technique validation and utility in diagnosing idiopathic normal pressure hydrocephalus. Neurosurgery 2002; 50(3): 534-43.
[PMID: 11841721]
[25]
Walhovd KB, Fjell AM, Reinvang I, et al. Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiol Aging 2005; 26(9): 1261-70.
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.05.020] [PMID: 16005549]
[26]
Jernigan TL, Gamst AC. Changes in volume with age- consistency and interpretation of observed effects. Neurobiol Aging 2005; 26(9): 1271-4.
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.05.016] [PMID: 16006011]
[27]
Chen G, Zheng J, Xiao Q, Liu Y. Application of phase-contrast cine magnetic resonance imaging in endoscopic aqueductoplasty. Exp Ther Med 2013; 5(6): 1643-8.
[http://dx.doi.org/10.3892/etm.2013.1062] [PMID: 23837047]
[28]
Sharma AK, Gaikwad S, Gupta V, Garg A, Mishra NK. Measurement of peak CSF flow velocity at cerebral aqueduct, before and after lumbar CSF drainage, by use of phase-contrast MRI: Utility in the management of idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg 2008; 110(4): 363-8.
[http://dx.doi.org/10.1016/j.clineuro.2007.12.021] [PMID: 18282655]
[29]
Guo Jinsong JY, Yue Yunlong. MR phase contrast film imaging to evaluate the efficacy of endoscopic aquaplasty in the treatment of obstructive hydrocephalus. Chinese J Med Comput Imag 2010; 26: 832-5.
[30]
Yao Weiwu CX, Shen Tianzhen. Quantitative study of MRI of cerebrospinal fluid before and after the ventricular shunt of communicating hydrocephalus. Chinese J Med Comput Imag 2003; 9: 12-6.
[31]
Thacker NA, Varma AR, Bathgate D, et al. Dementing disorders: Volumetric measurement of cerebrospinal fluid to distinguish normal from pathologic findings - feasibility study. Radiology 2002; 224(1): 278-85.
[http://dx.doi.org/10.1148/radiol.2241010419] [PMID: 12091696]


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Article Details

VOLUME: 17
ISSUE: 7
Year: 2021
Published on: 06 May, 2021
Page: [878 - 883]
Pages: 6
DOI: 10.2174/1573405617666210504093557

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